Does Study Claim a Cure? Beware of Scientific 'Spin'

From Drugs.com - September 11, 2017

Does Study Claim a Cure? Beware of Scientific 'Spin'

MONDAY, Sept. 11, 2017 -- Take with a grain of salt any flashy reports from clinical trials boasting groundbreaking results, a new scientific review warns.

A majority of clinical trials published in medical journals hype their findings, presenting them in a way that makes them look more favorable than they actually are, said senior researcher Lisa Bero.

An evidence review conducted by Bero and her colleagues found more than half of clinical trials "spin" their results either in the abstracts (summaries) or the main text of the published report.

"'Breakthrough' studies are quite rare, so any study making bold claims about [effectiveness] or causality should be viewed skeptically," said Bero, who's chair of medicines use and health outcomes with the University of Sydney in Australia.

"Science is an accumulation of knowledge, so new studies need to be put in the context of others," she added.

Spin or science hype involves different strategies, Bero said. These can include:

A hyped report might "conclude that a new treatment is beneficial when none of the results are statistically significant, or to suggest that a treatment or diagnostic test should be widely used based on the findings of a single, small study," Bero said.

To see how deeply such hype has infiltrated medical literature, Bero and her team reviewed 35 academic studies that individually attempted to assess spin in different fields of research.

Overall, the studies found that around 56 percent of clinical trials tended to hype their results. The presence of spin ranged from about 34 percent of reports from randomized clinical trials -- considered the gold standard of research -- up to 84 percent of papers written about non-randomized trials.

The researchers also found hype in 86 percent of papers on observational studies. These studies do not involve actual experiments, but instead try to discover new information by observing people's everyday lives.

Spin also was present in 26 percent of evidence reviews that attempt to sum up current medical knowledge by analyzing all the existing research, the findings showed.

Annette Flanagin is executive managing editor and vice president of operations for the Journal of the American Medical Association and the JAMA Network of publications. She said that this new analysis "provides more important information on the prevalence of biomedical studies with spin and describes the types of spin that are misleading and potentially deceptive."


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