'Upside' to Diabetes Really Isn't

From Drugs.com - September 13, 2017

'Upside' to Diabetes Really Is not

WEDNESDAY, Sept. 13, 2017 -- Type 2 diabetes can reduce your chances for a rare but potentially fatal weakness of blood vessels, a new study says. But while this may sound like good news, it's not.

Swedish investigators found that type 2 diabetes significantly decreases the long-term risks of aortic aneurysm and aortic dissection, two conditions that can lead to internal bleeding due to rupture of blood vessels.

But the mechanism that reduces risk for these rare conditions also increases your risk of developing hardened arteries, a much more serious health problem that can lead to heart attack and stroke.

"We have to make sure people do not think, 'Oh, good, I have diabetes type 2, this is good news -- because it's not," said Dr. Derek Brinster, director of aortic surgery at Lenox Hill Hospital in New York City. "You are at high risk if you have diabetes type 2 for dying earlier than you should from cardiovascular disease."

Aortic aneurysm is a balloon-like bulge caused by weakened walls of the aorta, the main artery that runs from the heart through the chest and abdomen.

Aortic dissection involves blood seeping through a tear in the inner lining of the aorta, causing the inner and outer layers of the blood vessel to separate.

Both conditions can cause the aorta to rupture, resulting in often-fatal internal bleeding. Popular actor John Ritter died from an undiagnosed aortic dissection in September 2003.

It has been known for at least two decades that diabetes decreases the risk of aneurysm, but the reasons behind this phenomenon are not clear, said Dr. Robert Eckel, a professor and chair of atherosclerosis with the University of Colorado Anschutz Medical Campus.

To further explore this association, researchers in Sweden led by Dr. Tarik Avdic from the Swedish National Diabetes Register compared data on more than 448,000 people with type 2 diabetes against 2.2 million people without diabetes.

They found that people with diabetes had a 28 percent decreased risk for aortic aneurysm and a 47 percent lower risk of aortic dissection when compared to people without diabetes.

The researchers theorized that high sugar loads in the bloodstream potentially strengthen the walls of blood vessels, making them less likely to balloon or tear.

However, the same process also could contribute to hardening of the arteries, said Brinster, who played no role in the study.


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