Selena Gomez's Kidney Transplant Puts Lupus Center Stage

From Drugs.com - September 15, 2017

Selena Gomez's Kidney Transplant Puts Lupus Center Stage

FRIDAY, Sept. 15, 2017 -- When pop star Selena Gomez revealed Thursday that she had a kidney transplant, she put the autoimmune disease lupus in the spotlight.

Lupus turns the body's immune system against itself and attacks vital organs, including the kidneys, which is why it's so devastating. But little is known about what causes the disease, and no real cure exists. Treatments can only keep it at bay.

"Selena has a lot of courage to speak out about her condition and call attention to lupus," said Dr. Anca Askanase. She is clinical director of the Lupus Center at Columbia University Medical Center in New York City.

Because Gomez needed a transplant at age 25, she probably developed lupus at an early age, added Askanase, who is also a spokeswoman for the Lupus Research Alliance.

The superstar singer first told Billboard in 2015 that she had been diagnosed with lupus and was undergoing chemotherapy. A year later, she took a career break and told People magazine at the time:

"I have discovered that anxiety, panic attacks and depression can be side effects of lupus, which can present their own challenges," Gomez said. "I want to be proactive and focus on maintaining my health and happiness, and have decided that the best way forward is to take some time off."

Gomez took more time off from her career this summer and emerged on Thursday with an Instagram photo revealing she had had the kidney transplant and was now recovering. Alongside her in the photo was the donor, actress Francia Raisa, a longtime friend.

"There are not words to describe how I can possibly thank my beautiful friend Francia Raisa," said Gomez. "She gave me the ultimate gift and sacrifice by donating her kidney to me. I am incredibly blessed."

Askanase said that half of all lupus patients develop kidney problems, but in younger patients, it's about 70 percent.

Of those who have kidney damage, about 10 percent to 15 percent end up needing dialysis or a transplant, she added.

"A large percentage of lupus patients do very well with a transplant, and part of that is because the medications used to prevent rejection are the same medications used to treat lupus," Askanase said.

"There is a 50/50 chance of making things better and a 20 percent chance of putting the disease in remission," she noted.

"We are still trying to understand which patients are going to have good outcomes and those who are not," Askanase said. "And lupus still carries a risk of death."

No one really knows how common lupus is, but what is known is that it is more common among women than men, and more common among blacks and Hispanics than whites, Askanase noted.

"It's a disease of young women," she said. "The peak time of diagnosis is between 15 and 34. The younger you are when you get lupus, the more aggressive the disease is."

Although it's not known what causes lupus, those who get it clearly are genetically disposed to it, Askanase added.

"There is also an environmental trigger, which can include infections like the Epstein-Barr virus," Askanase explained. "In addition, smoking may be a trigger."


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