Therapy Reverses Alzheimer's Brain Plaque Buildup -- in Mice

From - February 14, 2018

Therapy Reverses Alzheimer's Brain Plaque Buildup -- in Mice

WEDNESDAY, Feb. 14, 2018 -- Brain plaques believed to contribute to Alzheimer's disease melt away in mice when robbed of a key enzyme, researchers report.

And the rodents' intellectual function actually improved as their amyloid plaques dissolved from lack of beta-secretase (BACE1), an enzyme critical in the formation of the plaques, said senior researcher Riqiang Yan. He is vice chair of neuroscience with the Cleveland Clinic Lerner Research Institute.

The investigators had expected that blocking BACE1 would slow or halt the formation of amyloid plaques, but were surprised to find that it also caused existing plaques to fade away, Yan said.

"When we looked at the mice later -- at six months old and 10 months old -- all those pre-existing plaques were gone," Yan said. "Sequential deletion of beta-secretase actually can reverse existing plaques."

These results are good news for companies developing BACE1-inhibitor drugs as a potential treatment for Alzheimer's disease, Yan said. He noted that five such drugs are being tested in clinical trials.

Results have been mixed in these trials, but Yan said the drugs might have been started too late in the disease process to help Alzheimer's patients.

"Our findings should assure the pharmaceutical companies that if you treat people early enough, it not only can stop the growth of those plaques, but will likely help to even remove the existing plaque," Yan said.

Amyloid plaques are believed to contribute to Alzheimer's disease because the sticky clumps could interfere with communications between brain synapses. "In the Alzheimer's brain, a lot of those amyloid plaques accumulate and can cause neuronal loss and damage," Yan said.

Treatment using drugs that block BACE1 can be tricky because the enzyme controls many other important processes, the study authors said in background notes. For example, mice that completely lack BACE1 suffer severe defects in their early brain development.

To see whether inhibiting BACE1 in adult mice might be less harmful, Yan's team genetically engineered mice to gradually lose the enzyme as they grew older. These mice developed in a normal, healthy manner.

The researchers then bred those mice to another set of mice engineered to start developing amyloid plaques and Alzheimer's disease when they are 75 days old.

The offspring also started forming amyloid plaques at 75 days old, even though their BACE1 levels were half that of normal mice.

But as the mice continued to age and lose BACE1 activity, the plaques that already had formed in their brains began to disappear. By 10 months old, the mice had no amyloid plaques at all in their brains, the investigators found.

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